1 increased expression of intercellular enzymes of collagen synthesis Pinnell 1985. You see what happens when you consume plants you get anti-nutrients which block absorption of Vitamin C and many other vitamins and minerals. Oral doses of vitamin C cant raise blood levels of vitamin C nearly as high as intravenous doses given through injections.
Pharmacokinetic modeling predicts that even doses as high as 3 g ascorbic acid taken every 4 hours would produce peak plasma concentrations of only 220 micromolL 10. Vitamin C is required for your bodies correct functionality instead of asking whether you need Vitamin C the correct question is more along the lines of. 2 increased stabilization of procollagen mRNA Geesin et al 1988.
A few studies in animals and test tubes indicate that very high blood levels of vitamin C might shrink tumors. One site did say that a healthy dog produces 18mg of vitamin C per day per pound of body weight so you could roughly calculate your dogs vitamin C maintenance dose requirements using that formula. 3 induction of hydroxylation of lysine and proline amino acids a critical step in the formation of type I collagen in the lumen.
Vitamin C is relatively non-toxic even at very high doses. Tajima and Pinnell 1996. Vitamin C for pets in small animal and pet bird diets Naturally occurring ascorbic acid is highly sensitive to high.
To see why lets examine the vitamin C biosynthetic pathway. So if you have a 30-pound dog in your house under normal health conditions he should produce 540mg of Vitamin C per day. C-synthesizing animals produce vastly more vitamin C than the 90 mg government RDA C-producing animals radically increase production when faced with severe health challenges.